Our research has gained attention

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As we all struggle and work on our projects, let’s take a moment to congratulate ourselves on achieving high standards in our publications.

One of our studies on ADHD and immune system, published in Biological Psychiatry, was placed in the top 1% of the academic field of Neuroscience & Behavior based on highly cited threshold for the field and publication year, as of March/April 2017.

Bellow is the link for the article: “Attention Deficit Hyperactivity Disorder in Offspring of Mothers With Inflammatory and Immune System Diseases”

Our group was the first to perform a genome-wide association study on attention deficit hyperactivity disorder (ADHD) in Norway. The study became one of the top 25% most cited PLOS ONE articles in 2015.

Bellow you can find the link for the article: “Genome-Wide Analysis of Attention Deficit Hyperactivity Disorder in Norway”

So far, this article has been viewed 4,411 times and cited 16 times.

Congratulations!

Dette er min ADHD

Jeg har trodd at jeg er latere og dummere enn andre. De som klarer å lese bøker og alltid gjør ferdig leksene, og de som klarer å følge med og alltid har riktig svar, skriver kronikkforfatteren. (Illustrasjonsfoto) Foto: Scanpix / SCANPIX
Jeg har trodd at jeg er latere og dummere enn andre. De som klarer å lese bøker og alltid gjør ferdig leksene, og de som klarer å følge med og alltid har riktig svar, skriver kronikkforfatteren. (Illustrasjonsfoto)
Foto: Scanpix / SCANPIX

 

Jeg har aldri klart å slappe av. Jeg sliter med å følge samtaler fordi jeg ikke klarer å filtrere bort hverken intern eller ekstern støy. ADHD er ingen tullediagnose.

Det skriver Kamilla Paulsen i et innlegg på NRK Ytring.

 

Implication of the APP Gene in Intellectual Abilities

Craig Myruma,1, Oleksii Nikolaienkoa,1, Clive R. Bramhama, Jan Haavika,b and Tetyana Zayatsa,∗                   

aK.G. Jebsen Centre for Neuropsychiatric Disorders, Department of Biomedicine, University of Bergen,Norway bDepartment of Psychiatry, Haukeland University Hospital, Bergen, Norway

Abstract

Background: Cognitive functions are highly heritable and polygenic, though the source of this genetic influence is unclear. On the neurobiological level, these functions rely on effective neuroplasticity, in which the activity-regulated cytoskeleton associated protein (ARC) plays an essential role.

Objectives: To examine whether the ARC gene complex may contribute to the genetic components of intellectual function given the crucial role of ARC in brain plasticity and memory formation.

Methods: The ARC complex was tested for association with intelligence (IQ) in children from the Avon Longitudinal Study of Parents and Children (ALSPAC, N = 5,165). As Alzheimer’s disease (AD) shares genetics with cognitive functioning, the association was followed up in an AD sample (17,008 cases, 37,154 controls).

Results: The ARC complex revealed association with verbal and total IQ (empirical p = 0.027 and 0.041, respectively) in the ALSPAC. The strongest single variant signal (rs2830077; empirical p = 0.018), within the APP gene, was confirmed in the AD sample (p = 2.76E-03). Functional analyses of this variant showed its preferential binding to the transcription factor CP2.

Discussion: This study implicates APP in childhood IQ. While follow-up studies are needed, this observation could help elucidate the etiology of disorders associated with cognitive dysfunction, such as AD.

Read the article in IOSPress: Journal of Alzheimer`s Diseas

This article is also featured in Medical News Today.

brain-connections

Stimulus-evoked ERK-dependent phosphorylation of activity-regulated cytoskeleton-associated protein (Arc) regulates its neuronal subcellular localization.

oleksiiart2017

Highlights

  • ERK binds a non-canonical docking motif in the Arc C-terminal domain.
  • In vitro kinase assays identify five ERK phosphorylation sites on Arc.
  • Stimulus-evoked phosphorylation occurs on Ser206 in the central hinge region of Arc.
  • Phosphorylation regulates Arc subcellular localization in hippocampal neurons.
  • Endogenous Arc is Ser206 phosphorylated during LTP in live rats.

Development of Performance and ERPs in a Flanker Task in Children and Adolescents with Tourette Syndrome—A Follow-Up Study

 

Background: Tourette Syndrome (TS) is a neurodevelopmental disorder with childhood-onset, with a typical decline in tic severity, as well as an increasing ability to suppress tics in late childhood and adolescence. These processes develop in parallel with general improvement of self-regulatory abilities, and performance monitoring during this age-span. Hence, changes in performance monitoring over time might provide insight into the regulation of tics in children and adolescents with TS.

Method: We measured reaction time, reaction time variability, accuracy, and event-related potentials (ERP) in 17 children with TS, including 10 children with comorbid Attention-Deficit/Hyperactivity Disorder (ADHD), 24 children with ADHD, and 29 typically developing children, using a modified Eriksen Flanker task in two testing sessions administered on average 4.5 years apart. We then compared task performance, as well as ERP components across groups, and over time using regression models.

Results: Task performance improved in all groups with age, and behavioral differences between children with TS and controls diminished at second assessment, while differences between controls and children with ADHD largely persisted. In terms of ERP, the early P3 developed earlier in children with TS compared with controls at the first assessment, but trajectories converged with maturation. ERP component amplitudes correlated with worst-ever tic scores.

Conclusions: Merging trajectories between children with TS and controls are consistent with the development of compensatory self-regulation mechanisms during early adolescence, probably facilitating tic suppression, in contrast to children with ADHD. Correlations between ERP amplitudes and tic scores also support this notion.

Prevalence and clinical correlates of insomnia in adults with attention-deficit hyperactivity disorder

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Abstract

Objective

To investigate the prevalence of insomnia in adults with Attention-deficit hyperactivity disorder (ADHD) and its association with clinical subtypes, current ADHD symptoms, and stimulant treatment.

Method

We obtained diagnostic information, symptom rating scales and treatment history from clinically ascertained adult ADHD patients diagnosed according to DSM-IV criteria (n = 268, mean age 38.1 years) and randomly selected population controls (n = 202, mean age 36.5 years). The Bergen Insomnia Scale (BIS) was used to measure insomnia. ADHD symptom domains were self-rated using the Adult ADHD Self-Rating Scale.

Results

Insomnia was far more frequent among adults with ADHD (66.8%) than in the population controls (28.8%) (P < 0.001). Insomnia was more common in adults with the combined subtype than in those with the inattentive subtype (79.7% and 55.6%, respectively) (P = 0.003). For self-reported current ADHD symptoms, inattention was strongly correlated to insomnia. Patients currently using stimulant treatment for ADHD reported a lower total insomnia score compared to patients without medication (P < 0.05).

Conclusion

Insomnia was highly prevalent among adults with ADHD. The lower insomnia score in patients on current stimulant treatment suggests that stimulant treatment is not associated with worsening of insomnia symptoms in adult ADHD patients.

ADHD in The New York Times

Patient Voices: A.D.H.D.

About 6.4 million children in the United States have been given diagnoses of attention deficit hyperactivity disorder (A.D.H.D.). But the condition — characterized by impulsiveness and difficulty sitting still and paying attention — is also being recognized more in adults. The challenges faced by those with A.D.H.D. are daunting and deeply personal. Here, in their own words, are the stories of adults and children coping with A.D.H.D. Read more..

Reisebrev fra CoCA-møte i Barcelona

Fra 19. til 21. mars var tre av KG Jebsen-senterets medlemmer på et møte i Barcelona for å diskutere fremgangen i et EU-prosjekt vi er partnere i. EU-prosjektet heter «Comorbid Conditions in ADHD» (CoCA) og inkluderer 17 forskningsgrupper/partnere fra ni land. CoCAs overordnede mål er å bedre kartlegge, forstå og behandle andre sykdommer og lidelser som opptrer samtidig med ADHD, for eksempel depresjon, angst og søvnforstyrrelser. Mer spesifikt er det flere delprosjekt, blant annet en klinisk studie på behandling av depresjon og overvekt hos ADHD-pasienter ved hjelp av lysterapi og fysisk aktivitet, genetiske studier for å undersøke felles underliggende genetikk mellom forskjellige lidelser, hjerneavbildningsstudier også videre. Vårt senter bidrar hovedsakelig først og fremst med epidemiologisk forskning og genetisk forskning; i tillegg til at vi leder et prosjekt hvor vi forsøker å finne nye medisiner for behandling av ADHD og beslektede lidelser.

Kort fortalt skjedde det mye spennende i alle delprosjektene og fremgangen kan sies å være god. Videre er det også hyggelig å møte folk man samarbeider med ansikt-til-ansikt, samtidig som at alle diskusjoner blir mye mer effektive. Problemstillinger som tar to uker å avklare på email og Skype, blir avgjort på fem minutter. Vi fikk derfor lagt en god del konkrete planer for de neste månedene. Dessverre var det veldig travelt alle dagene så det ble begrensede muligheter for sightseeing…

Pressemelding fra 2016 ved oppstart av CoCA-samarbeidet
http://www.ru.nl/donders/agenda-news/vm-news/6-mio-euro-coca-research-adhd/

Blogginlegg om studien på lysterapi og aktivitetsterapi ved ADHD
https://mind-the-gap.live/2017/02/18/coca-proud-trial-ready-to-roll/

 

cocabarcelona20mars2017

Tor-Arne Hegvik, PhD student

Top 10 RNA-Seq Publications of All Time

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“RNA-Seq is the most likely NGS technique to be used by researchers in 2017 due to its versatility”

 

 

 

RNA-seq has become a ubiquitous tool in both biological and medical research. Much of the RNA-seq analysis done is still for differential gene expression from poly-adenylated mRNAs; but the success of RNA-seq can also be seen in the rapid increase in knowledge about biological systems and the large number of distinct variants of the method.  The combination of these factors allow us to go much further than the ‘simple’ 3’ gene expression microarrays and now opens up the possiblities of: splicing analysis, differential allele expression, variant detection, alternative start/stop, gene fusion detection, RNA editing and eQTL mapping to name but a few…

Continue reading Top 10 RNA-Seq Publications of All Time